Reaction
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Timing
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Signs and symptoms
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Anaphylactic reaction (severe allergic reaction)
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Call 911 if your child has:
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Shortness of breath and labored breathing
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Wheezing
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Red face (flushing)
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Hives
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Low blood pressure
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Fast pulse
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Chest tightness
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Swelling of the lips, tongue, or throat
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Bacterial infection (sepsis)
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May happen 30 minutes or more after the transfusion
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Fever, shaking chills, fast heartbeat, and low or high blood pressure
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Allergic reaction (mild)
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Hives or red welts on the skin, mild itching, rash, localized swelling, flushing (red face), wheezing, shortness of breath, or high-pitched noise or sound (stridor)
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Febrile nonhemolytic reaction
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Fever, chills, flushing, upset stomach (nausea), headache, minor discomfort, or mild shortness of breath
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Acute immune hemolytic reaction
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Fever, red or brown urine, back pain, fast heart rate (tachycardia), abdominal pain, low blood pressure, feeling anxious, chills, chest pain, nausea, or fainting spells
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Transfusion-related acute lung injury (TRALI)
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Shortness of breath, trouble breathing, low blood pressure, fever, pulmonary edema
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Transfusion-associated circulatory overload (TACO)
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Shortness of breath, fast heart rate (tachycardia), problems breathing when lying on back, abnormal blood pressure
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Post-transfusion purpura (PUP)
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Purple spots on skin; nosebleed; bleeding from the urinary tract, abdomen, colon, or rectum; fever; or chills
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"Delayed" transfusion-related acute lung injury (TRALI)
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Sudden onset of respiratory distress or trouble breathing
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"Delayed" hemolytic reaction
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Low-grade fever, mild yellowing of the skin and whites of the eyes (jaundice), decrease in hematocrit, chills, chest pain, back pain, nausea
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